Journal: Journal of Alzheimer's Disease Reports
Article Title: An experimental framework for conjoint measures of olfaction, navigation, and motion as pre-clinical biomarkers of Alzheimer's disease
doi: 10.1177/25424823241307617
Figure Lengend Snippet: Proposed practical application of the experimental framework for conjoint study of olfactory and spatial disorders. Self-use of commercially available and affordable OI, ACC, and GPS tests facilitates broad, cross-cultural data collection. An AI-driven analytic tool cross-references the data with OI, gait speed, navigation patterns, and biomarker datasets in a privacy-protective manner, indicating potential AD risk. Non-invasive blood-based biomarkers can further strengthen the preclinical indications. Focusing costly, invasive clinical biomarker testing and prospective treatment administration on at-risk candidates could reduce economic costs and improve patients’ quality of life. The early AD diagnosis could prepare patients and their carers for the disease course. ACC: accelerometry; AD: Alzheimer's disease; AI: artificial intelligence; BSIT ® : Brief Smell Identification Test ® ; GPS: Global Positioning System; UPSIT ® : University of Pennsylvania Smell Identification Test TM .
Article Snippet: A study of sleep behavior disorder as a Parkinson's disease biomarker monitored gait continuously with a validated ACC sensor (Axivity AX3).
Techniques: Biomarker Discovery